ITCH AND INFLAMMATION

THE CAUSE

Although the cause of prurigo nodularis (PN) is not entirely understood, it is thought to begin inside the body, where an abnormal relationship between the skin, nervous system, and immune system can lead to inflammation.

UNRELENTING ITCH

Inflammation results in the signs and symptoms you see and feel, like unrelenting itch.

THE ITCH-
SCRATCH CYCLE

This unrelenting itch leads to scratching and the development of itchy bumps over time, resulting in more scratching and rubbing. Chronic scratching can lead to scarring.

About PN

PN is an uncommon chronic inflammatory skin disease that primarily affects adults. Signs and symptoms include itch lasting 6 weeks or longer, a history of repeated scratching, picking, or rubbing of the skin, and the presence of bumps.

Key Characteristics:

  • Hard, itchy bumps (nodules) distributed on the body
  • Extreme itchiness that leads to frequent scratching, bleeding, and potentially more bumps
  • Symptoms may worsen with sweat, heat, stress, and certain
    fibers in clothing

Common Areas Affected:

  • Arms
  • Legs
  • Upper back
  • Lower back
  • Chest
  • Abdomen
Pictures of prurigo nodularis (PN) on various skin tones and different body parts

the look of pn on your skin

While the symptoms may be similar, PN can appear differently depending on the color of your skin. Explore the PN Skin Gallery to see prurigo nodularis on a wide range of skin tones.

Go to the gallery

Facts About Prurigo Nodularis

An Uncommon disease
that is widely
misunderstood and
frequently misdiagnosed
~139K
adult patients using
topical prescriptions
still have uncontrolled
symptoms
~311K
adults impacted in
the USA
Women
have a higher
prevalence of PN

ALL ABOUT PN

It’s time to clear up some misconceptions about PN. Watch an actual DUPIXENT patient share facts about this condition.

FINd out how
dupixent can help pn