HOW DUPIXENT WORKS

Learn About a Treatment for Adults With Prurigo Nodularis (PN)

Hi, everyone. My name is Sydney.

I’ve been diagnosed with prurigo nodularis, also known as Picker’s Nodules, Nodularis Prurigo, and Eczema Prurigo. My healthcare team and I call it PN.

I'm on my way to an appointment with my skin specialist right now to speak about DUPIXENT® (dupilumab), the first FDA-approved treatment for PN in adults.

It’s a biologic that may help you stay one step ahead of PN symptoms.

And here’s some IMPORTANT SAFETY INFORMATION. Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Stay tuned until the end of my story, where you’ll see additional Important Safety Information.

Because PN is uncommon, it made it difficult to diagnose—and hard for me to discuss my symptoms and how they affect me.

In fact, at one point I was even told it might all be in my head!

Say what you will about unicorns, but PN is one hundred percent real.

My PN symptoms—the intense itch and painful nodules—are persistent and can’t be ignored.

My skin specialist explained that PN is a chronic disease that begins inside the body. Research suggests that an abnormal relationship between the skin, nervous system, and immune system can lead to inflammation.

On the surface of the skin, I feel an intense itch and see the development of bumpy lesions, or nodules, over time.

Mine are typically brown, but they can also be pink, red, or a range of other colors based on your skin tone.

Beneath your skin, there are immune cells and nerve cells, both of which affect the health of your skin.

In fact, they all have an impact on each other.

Immune cells send out inflammatory, or “warning,” signals to help protect the skin.

Nerve cells, which are located in the skin, signal sensations, like itchiness, to the brain.

But when you have PN, your nerves may send too many itch signals to the brain. This can lead to intense itching.

Because of the constant itching and scratching, the immune cells in your body send out too many inflammatory signals. This results in chronic inflammation and more itching.

And continued scratching can result in painful nodules that can cause burning and stinging sensations, bleeding, or scarring on your skin. It’s a vicious cycle!

While I have tried other options, they aren’t always enough to help with the intense itching and appearance of nodules.

My skin specialist and I agree that DUPIXENT may be the right treatment approach for me to try now because DUPIXENT may help bring balance by controlling a source of chronic inflammation under the surface of the skin, to help me stay one step ahead of PN symptoms.

In two clinical studies with 311 adults with PN, almost 3 times as many adults had less itch at 24 weeks, and in one study, some adults had less itch in as little as 12 weeks.

Also, almost 3 times as many adults had skin clear or almost clear of PN bumps at 24 weeks.

The most common side effects in patients with prurigo nodularis include eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, herpes virus infections, common cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea.

If what I’ve shared about PN sounds familiar to you, it may be time to ask about DUPIXENT!

Check out the DUPIXENT.com symptom tracking tool and doctor discussion guide to help you have a more productive conversation with your skin specialist.

Thanks for letting me share what I’ve learned with you today!

Stay tuned to hear important safety information about DUPIXENT.