Pixi: Hi! I’m Pixi, and I’m here to help you and your loved ones learn about DUPIXENT® (dupilumab). In just a few seconds, you’re going to hear David, an adult living with eosinophilic esophagitis, also known as EoE, have a discussion with his gastroenterologist. They’ll talk about some common challenges of living with EoE and how DUPIXENT may be able to help.

DUPIXENT is a prescription medicine used to treat adults and children 1 year of age and older with eosinophilic esophagitis (EoE), who weigh at least 33 pounds (15 kg). It is not known if DUPIXENT is safe and effective in children with eosinophilic esophagitis under 1 year of age, or who weigh less than 33 pounds (15 kg).

Please listen to the full Important Safety Information and Indication at the end of this audio, and please see links for full Prescribing Information including Patient Information above.

If you live with EoE or are the caregiver of someone with EoE, you can use this resource to help navigate your next doctor appointment.

Gastroenterologist: David, it’s good to see you. How are things going?

David: Not so good, actually. I’ve been frustrated lately because it seems like my EoE is getting worse—I feel like I need to try something new to help manage my symptoms.

Gastroenterologist: Well, I don’t like to hear that you’ve been feeling so bad, but I’m glad you’re telling me so we can try to do something about it. Tell me a bit more about what’s been going on.

David: Well, it’s been harder for me to eat since my last visit. I’ve limited my diet a lot but I still have difficulty swallowing. I haven't been able to eat many of the foods I enjoy. I even had to stop eating some of the foods that my dietician suggested, like plain chicken cut up into small pieces.

Gastroenterologist: OK, so trouble swallowing is getting even worse—got it. What about other symptoms? Any pain when swallowing?

David: Yeah. Actually, this past weekend, I had pain swallowing at a neighborhood barbecue. Even though I was only eating soft foods, I just couldn’t get them down. I had to leave right in the middle of the party.

I used to enjoy family dinners and going out to eat with my friends—but I just prefer to eat alone at this point.

Gastroenterologist: That sounds stressful, and I want to help you manage your condition. And you're still taking your proton pump inhibitors, or PPIs?

David: Yeah, I’ve been taking my PPIs and a swallowed steroid twice a day. I’ve even tried running all of my food through a blender to help make it easier to swallow. I feel like I'm doing everything I can, but my symptoms are just getting worse.

Gastroenterologist: Well, you've done a great job following your management plan, but I see what you mean—if I were in your shoes, I would be frustrated, too.

David: It can be frustrating. I don’t feel like my symptoms are under control. I was going to ask you about this medicine I’ve been discussing with my family called DUPIXENT.

Gastroenterologist: Ah yes, DUPIXENT. You’re not the first patient of mine to ask about it. In fact, I have other patients who take DUPIXENT, and I think it may be a good option for you. DUPIXENT is a biologic and is actually the first FDA-approved treatment for patients ages 1 year and older who weigh at least 33 lb with EoE. DUPIXENT was proven to reduce difficulty swallowing and may help manage your other EoE symptoms.

David: Can you explain what a biologic is? Is it different from the medicines I’m taking now?

Gastroenterologist: Many of my patients have had the same questions. I wanted you to first try a PPI and a swallowed steroid, along with diet modification, to help control your symptoms.

But since you're still experiencing symptoms, I think DUPIXENT may be a good option for you. It’s not a steroid; it’s a biologic medicine, so the body processes it differently than the other medicines I’ve prescribed you before. It’s also not an immunosuppressant. DUPIXENT works by targeting an underlying source of inflammation, which is a cause of EoE.

David: That makes sense. Do you think DUPIXENT could help give me relief?

Gastroenterologist: It might! But remember, everyone’s experience will be a little different. Results with DUPIXENT may vary.

David: Does it have any side effects?

Gastroenterologist: Yes, DUPIXENT has side effects—some serious and others more common—that we should discuss. DUPIXENT may cause allergic reactions that may sometimes be severe as well as joint aches and pain. The most common side effects in patients with eosinophilic esophagitis include injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).

David: Thanks for letting me know. I do have one concern—since I’ve been having difficulty swallowing lately, what if I can’t take it?

Gastroenterologist: Well, DUPIXENT is a subcutaneous injection, which means that it is given under the skin.

David: Oh. Well—I’m glad I won’t have to swallow pills or anything, but I’ve never taken an injectable medicine before. I don’t know how to inject myself…

Gastroenterologist: Don’t worry. My nurse will give you the first dose here in the office. Afterward, one of my nurses will train you, so you’ll know the right way to prepare and inject DUPIXENT. Once you feel comfortable injecting yourself, you’ll use a pre-filled pen or syringe to give yourself a dose of DUPIXENT once a week.

Before I forget—I also wanted to mention that my other patients on DUPIXENT have told me that they’ve enrolled in the DUPIXENT MyWay® Patient Support Program. They’ve found it helpful because it gives them access to things like supplemental injection training videos that you can watch by yourself or with loved ones. If you’d like, you can also call a Nurse Educator for support. They’re trained healthcare professionals who only work with DUPIXENT patients, so they can answer many of your questions. Of course, as your doctor, I’m the best person to talk to for anything specific to your care or treatment plan.

David: That sounds great! DUPIXENT seems like it may be an option for me, but how do I know if I can afford it?

Gastroenterologist: There’s a copay card that can help with the cost of DUPIXENT, if you’re eligible. You can also call a Nurse Educator for help navigating the insurance process. Our office manager can help check to see if your insurance covers DUPIXENT and what the cost to you will be.

David: Oh, that’s good to hear!

Gastroenterologist: So, do you think you would like to try DUPIXENT?

David: Absolutely! I’m tired of my frequent symptoms. I’m ready to try to take control of my EoE!

Pixi: Nice work navigating that conversation, David! He did a great job of being honest and direct about his concerns and asking questions in order to learn how DUPIXENT may be able to help him.

For more help preparing for your next appointment, you can also download our helpful Doctor Discussion Guide on DUPIXENT.com/EoE. Fill it out by yourself or with loved ones, and bring it to your next appointment with your EoE specialist to help have an informed conversation about DUPIXENT.

For additional support, or to learn about the DUPIXENT MyWay Copay Card and other financial assistance programs, contact the Nurse Educators at 1-844-DUPIXENT (1-844-387-4936), option 1.