frequently asked
questions

DUPIXENT is a prescription medicine used to treat adults and children 12 years of age and older, who weigh at least 88 pounds (40 kg), with eosinophilic esophagitis (EoE).

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Fill out our personalized doctor discussion guide to help guide your conversation with your doctor and discover whether DUPIXENT may be right for you.

DUPIXENT targets an underlying source of inflammation that contributes to EoE.

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How DUPIXENT Works

Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.

Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:

• have a parasitic (helminth) infection
• are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
• are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call
    1-877-311-8972 or go to
    https://mothertobaby.org/ongoing-study/dupixent/.
• are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have EoE and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

The effectiveness and safety of DUPIXENT has been studied in a 2-part clinical trial with 240 adult and pediatric (ages 12-17) subjects with eosinophilic esophagitis (EoE).

• DUPIXENT was proven to reduce difficulty swallowing and reduced eosinophils in the esophagus, which contribute to inflammation.

Patients enrolled in these studies included subjects who had a history of prior use of swallowed topical corticosteroids for the treatment of EoE, as well as subjects with a history of prior esophageal dilation.

The most common side effects in adult patients were injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).

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With DUPIXENT

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:

• Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects of DUPIXENT include: injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

DUPIXENT is a form of medicine called a biologic. It is not an immunosuppressant or a steroid.

Biologics are processed in the body differently than oral or topical medications. Most biologic medications come as liquids and should be administered by injection. Today, different biologics are used to treat many conditions you may be familiar with.

Endoscopic biopsy is a procedure in which abnormal tissue in the esophagus is sampled so it can be checked under a microscope for signs of a disease.

Eosinophilic esophagitis (EoE) is a chronic and progressive condition in which immune cells (eosinophils) build up within the esophagus. This buildup is associated with an abnormal response of the immune system, known as Type 2 inflammation. Over time, this can cause damage to the esophagus.

One of the most common EoE symptoms, dysphagia is difficulty swallowing foods or liquids due to swelling in the esophagus.

Food stuck firmly in the esophagus is called “food impaction.” This can be a medical emergency if the food does not go down the esophagus into the stomach or is not vomited up relatively quickly.

A gastroenterologist is the only type of doctor who can diagnose EoE.

The procedure for diagnosing EoE is called an endoscopy with biopsy. During this procedure, a gastroenterologist (GI) uses a thin tube to look at the esophagus and take tissue samples. The GI may then diagnose EoE based on your symptoms, the appearance of the esophagus, or the number of eosinophils in the tissue sample.